In conclusion, CNS immune-mediated adverse events of COVID-19 vaccination appear to be very rare and consist mostly of Ab-negative AE, myelitis, and ADEM developing approximately 2 weeks after vaccination, when a mounting robust CD8+ T cell response is suggested by the increased CXCL10 CSF levels. The gene discussed is CXCL10; the disease is acute disseminated encephalomyelitis.