Initially identified on CTLs and Th1 cells, Tim-3 inhibits type 1 immune responses, suppressing cytokine generation, including TNF and INF-γ (228, 234, 235) and is expressed in various tumor cells and immune cells including Th17, Tregs, TILs, natural killer (NK) cells, macrophages, and DCs (228, 236–243). The gene discussed is HAVCR2; the disease is neoplasm.