In sepsis, blood and spleen leukocytes go to hyporesponsive in the acute disease stage, such as tolerance in these hematopoietic compartments. However, the functionality of alveolar macrophages, liver kupffer cells, intestinal epithelial lymphocytes, microglia cells, and skin’s CD8 T-cells was shown to be unaffected or primed (71) (72). Thus, compartments other than the blood participate in shaping immunosuppression. This evidence concerns the gene CD8A and Sepsis.