Notably, INSR also demonstrated a negative correlation with T2D prevalence, as evidenced in among the MR Egger analysis (OR = 0.889, 95%CI = 0.837–0.944, p = 0.001), the WM analysis (OR = 0.910, 95%CI = 0.872–0.950, p = 1.52 × 10–5), and IVW analysis (OR = 0.941, 95%CI = 0.908–0.975, p = 6.68 × 10–4) (Figure 5). This evidence concerns the gene INSR and type 2 diabetes mellitus.