Notably, IGFBP-5 also exhibited a negative correlation with T1D prevalence, as evidenced in both the WM analysis (OR = 0.838, 95%CI = 0.720–0.975, p = 0.022) and IVW analysis (OR = 0.882, 95%CI = 0.778–0.999, p = 0.049). This evidence concerns the gene IGFBP5 and type 1 diabetes mellitus.