IGFBP5 and type 1 diabetes mellitus: Additionally, genetically lower levels of IGF-1 and IGFBP-5, along with higher levels of IGFBP-7, were associated with an increased risk of Type 1 Diabetes (T1D) (IGF-1, OR 0.981 [95% CI 0.963–0.999], p = 0.037; IGFBP-5, OR 0.882 [95% CI 0.778–0.999], p = 0.049; IGFBP-7, OR 1.103 [95% CI 1.008–1.206], p = 0.033).