In contrast, a higher serum concentration of IGFBP-6 exhibited a positive correlation with a reduced risk of T2D, as demonstrated by both the IVW approach (OR = 0.92, 95%CI = 0.87–0.98, p = 0.01) and the WM method (OR = 0.93, 95%CI = 0.87–1.00, p = 0.04). The gene discussed is IGFBP6; the disease is type 2 diabetes mellitus.