Normal mLN NK cells did not express LAG-3 or TIM-3, whereas mLN NK cells of tumor-bearing mice expressed higher LAG-3 and TIM-3 to generate two NK subsets: LAG-3+TIM-3hi NK cells and LAG-3-/loTIM-3-/lo NK cells (Fig. 2A). This evidence concerns the gene LAG3 and neoplasm.