STAG3 and ovarian dysfunction: However, given the associations between STAG3 and ovarian insufficiency, the eQTL linking rs2267812 with STAG3L2 expression in the postmortem brain, and the alternative STAG3L2 transcript that spans the entire significant GWAS locus, STAG3L2 appears to be the more likely candidate responsible for the differential impacts on pubertal timing observed in individuals with WS and Dup7.