Surprisingly, the directionality of this finding was such that expression of STAG3L2 was highest in individuals with WS (who have hemideletions) and lowest in individuals with Dup7 (who have an extra copy of the ∼25 genes in the WS 7q11.23 locus), suggesting that hemideletion of this region may include the removal of regulatory element(s) that inhibit STAG3L2 transcription. This evidence concerns the gene STAG3L2 and Werner syndrome.