Multivariate Cox analysis (univariate analysis p < 0.05) showed that smoking index and Ki-67 expression were independent prognostic factors for PFS (p < 0.05) in EBM patients; TNM stages and Ki-67 expression were also independent prognostic factors for PFS (p < 0.05) in LBM patients (Table 3). This evidence concerns the gene MKI67 and bullous dystrophy, macular type.