EGFR and non-small cell lung carcinoma: reported that the median PFS and OS in TP53 wild type were the longest compared to exon 4 or 7 of TP53 and other TP53 mutations (p < 0.05), indicating TP53 as a promising predictive and prognostic indicator in EGFR-mutated advanced NSCLC on EGFR-TKIs (21).