While according to some other restudies, PEDF reduces and reverses HFD-induced obesity, hepatic steatosis and hepatic fibrosis and improves insulin sensitivity and white adipose tissue inflammation in vivo (55, 56).In our cohort, we observed a significant association between PEDF levels and three time points. This evidence concerns the gene SERPINF1 and obesity due to melanocortin 4 receptor deficiency.