CCN2 and cardiac hypertrophy: In vitro, Exogenous CTGF stimulation can not only lead to cardiomyocyte hypertrophy, but also promote the proliferation of cardiac fibroblasts and the deposition of extracellular matrix (8, 20); In vivo, studies have shown that CTGF expression of cardiac tissue was upregulated in animal models of hypertrophic cardiomyopathy and MI (21, 22), while cardiac fibrosis and myocardial hypertrophy are important pathogenesis of LV diastolic dysfunction, and there are few studies investigating the association between plasma CTGF level and LV diastolic dysfunction.