CCN2 and hyperthyroidism: However, inconsistently, the ROC showed that plasma CTGF levels were more likely to be used for the diagnosis of LV diastolic dysfunction compared with serum BNP levels and BNP/CTGF ratios, suggesting that measuring plasma CTGF levels is more valuable in the diagnosis of LV diastolic dysfunction in patients with hyperthyroidism, but larger studies are needed.