However, inconsistently, the ROC showed that plasma CTGF levels were more likely to be used for the diagnosis of LV diastolic dysfunction compared with serum BNP levels and BNP/CTGF ratios, suggesting that measuring plasma CTGF levels is more valuable in the diagnosis of LV diastolic dysfunction in patients with hyperthyroidism, but larger studies are needed. This evidence concerns the gene NPPB and hyperthyroidism.