SHBG and diabetes mellitus: However, a causal association was identified between several other factors, including testosterone, high-density lipoprotein, sex hormone-binding globulin, body mass index, waist-hip ratio, apolipoprotein A-I, number of children, illnesses of parents and siblings (diabetes), hemoglobin A1c, fasting insulin, fasting blood glucose, years of schooling, and GDM.