Furthermore, a comparison of all 14 hub genes expression counts data in single-cells of pancreatic cancer (Supplementary Figure 4C) and its para-cancerous tissues (Supplementary Figure 5C) revealed that the expression levels of RARRES3 and TNFSF10 were most significantly increased in PAAD single-cell samples compared with normal. The gene discussed is PLAAT4; the disease is pancreatic neoplasm.