The serine/threonine kinase AKT, also known as protein kinase B (PKB), is a proto-oncogene that has three isoforms, AKT1 (PKBα), AKT2 (PKBβ), and AKT3 (Pub), which have markedly different or even opposing functions in cancer and physiology [159–161]. The gene discussed is AKT1; the disease is cancer.