Given the potential advantages of accurately predicting the risk of malignancy, the International Ovarian Tumour Analysis (IOTA) group developed the Assessment of Different Neoplasias in the adnexa (ADNEX) risk prediction model, based on three clinical and six ultrasound predictor variables.5 The clinical variables are age, serum levels of the biomarker, cancer antigen 125 (CA125), and type of centre (oncology centre v other). The gene discussed is MUC16; the disease is ovarian neoplasm.