There was a hyperactivation of keratinization pathways associated with CRNN overexpression [36] and overexpression of proinflammatory cytokines, including IL23A, S100A7, and IL1A (log2fc > 1, p-value < 0.05) in Ghanaians with severe COVID-19 compared with mild (Figures 2(c) and 3(a)–3(d). Here, S100A7 is linked to COVID-19.