Recent studies suggest that pharmacological activation of the 5-hydroxytriptamine (5-HT)1F receptor (HTR1F) increases PGC-1α, MB and mitophagy, and accelerates recovery in an AKI mice model (Garrett et al., 2014; Hurtado et al., 2023a; Hurtado et al., 2023b). Here, HTR1F is linked to acute kidney injury.