MAPK8 and malignant colon neoplasm: This effect was diminished by inhibition of the downstream signaling pathway JNK/p38 but not by inactivation of extracellular signal-regulated kinases, suggesting that baicalein induces a positive feedback loop between Gadd45a and JNK/p38 to promote the activation of MAPKs through the upregulation of DEPP, leading to an apparent apoptotic response in human colon cancer cells.