Another study found that the levels of protein phosphorylation of the PI3K, AKT, and GSK-3β protein phosphorylation levels decreased after baicalin treatment, suggesting that inhibition of the PI3K/AKT/GSK-3β pathway also plays an important role in the inhibition of CRC cells migration by baicalin (Liu et al., 2019; Li et al., 2021). The gene discussed is GSK3B; the disease is colorectal carcinoma.