In addition to the above results detected in some studies, the treatment of CRC cells resulted in nuclei agglutination, sequestration, and formation of apoptotic vesicles of the nuclei, as well as a concentration and dose-dependent increase in the activity of necrosis factors TNFTP53, TP53BP2, TNF and downstream caspase-3, caspase-8, and caspase-9, which were detected. Here, TNF is linked to colorectal carcinoma.