In line with our data, treatment of bovine aortic endothelial cells with Gb3 induced the expression of angiogenic factors such as TGfβ, VEGFR2, VEGFα, and FGF2 (3, 25), demonstrating a pivotal role of angiogenetic factors in Gb3-induced vasculopathy. The gene discussed is KDR; the disease is vascular disorder.