We further investigated how 4-carbomethoxyl-10-epigyrosanoldie E impacts the levels of proteins such as FAK, PKC, GRB2, Rac, Ras, RhoA, MEKK3, and MKK7, which are upstream regulators in the MAPK pathway and play a role in controlling the expression of MMPs involved in cancer cell metastasis. The gene discussed is MAP3K3; the disease is cancer.