DNM1 and cryohydrocytosis: Nonetheless, the pleiotropic and off-target effects of these drugs have been described, as dynasore also presents dynamin-independent effects such us the disruption of lipid rafts, and pitstop 2 was reported to have additional cellular targets besides CHC (Macia et al., 2006; Dutta et al., 2012; Preta et al., 2015).