Cheng et al. (2018) found that circVMA21 can adsorb miRNA-200c, reduce the expression of its target X-linked inhibitor of apoptosis protein (XIAP), and successfully alleviate the degenerative changes of NP by injecting circVMA21 into a rat IDD model. Du et al. (2022) found that the expression of circ_0083756 exhibited a significant rise in degenerative NP tissues and cells, adsorbing miRNA-558, promoting the process of IVD, and alleviating IDD in a rat model by silencing circ-83756. This evidence concerns the gene XIAP and intervertebral disk degenerative disorder.