MMP2 and intervertebral disk degenerative disorder: Feng et al. (2018) selected miR-29a in the miRNA-29 (miR-29) family, which has been proven to have the ability to inhibit fibrosis, and sent miR-29a into the IVD, effectively silencing the expression of MMP-2, significantly slowing down IVD fibrosis, and achieving MMP inhibition. In another study, Ji et al. (2018) selected miRNA-141, the expression of which is associated with IDD grading and has been evidenced to be indispensable in the pathogenesis of IDD.