EMT is also thought now to be involved in carcinoma cells’ acquisition of stem-like properties7–10 and resistance to anti-cancer drugs.11–15 As a transient and reversible cellular process, EMT could allow interconversions of CSCs and non-CSCs, by decreasing (e.g., E-cadherin) and increasing the expressions of EMT factors (e.g., vimentin, N-cadherin, ZEB, SNAIL, and TWIST).2,16 Among the EMT factors, transcription factors (e.g., TWIST, ZEB, and SNAIL) are particularly important for EMT initiation,17 stemness acquisition,7,9,10,16 and resistance to chemotherapy.18 This evidence concerns the gene SNAI1 and cancer.