HTT and amyotrophic lateral sclerosis: This includes the mutant Htt associated with HD, C9orf72 of amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) and NOP56 of spinocerebellar atrophy type 36 (SCA36) (Liu et al, 2012; Cheng et al, 2015; Kramer et al, 2016; Furuta et al, 2019).