In this study, we immunostained a relatively large number of EMPD clinical samples and conducted several in vitro analyses using our newly established EMPD cell line, KS-EMPD-1 60, in order to investigate the role of FOXM1 in the tumorigenesis of this disease and examine FOXM1 as a potential therapeutic target of EMPD. The gene discussed is FOXM1; the disease is extramammary Paget disease.