In addition, it inhibits EMT in cervical cancer by targeting Nocth1 (Wei et al. 2021), alleviates the occurrence and progression of femoral head osteonecrosis through mediating the murine double minute homolog 4/tumor protein (MDMX/p53) pathway (Yang, et al. 2022), and represses kidney fibrosis via calcium-calmodulin dependent protein kinase II (CaMKII) (Park et al. 2018). Here, MDM4 is linked to familial avascular necrosis of femoral head.