RBFOX1 and psychiatric disorder: Our results show that the damaging effect of a mutation in rbfox1 may be modulated by genetic and environmental effects and therefore lead to different phenotypes, which is also in line with the different diagnosis of patients with rare CNVs or point mutations in the RBFOX1 gene as well as the contribution of common variants to different psychiatric disorders [6, 10, 11, 14, 46].