RBFOX1 and major depressive disorder: Interestingly, common variants in RBFOX1 were found significantly associated with the cross-trait phenotype of the most recent genome-wide association studies (GWAS) meta-analysis of psychiatric disorders [13] and RBFOX1 was identified as the second most pleiotropic locus in a previous cross-disorder GWAS meta-analysis, showing association of common variants with attention-deficit/hyperactivity disorder (ADHD), ASD, bipolar disorder (BIP), major depression (MD), obsessive-compulsive disorder, schizophrenia (SCZ) and Tourette’s syndrome (TS) [14].