FH and hereditary clear cell renal cell carcinoma: It is well known that in the occurrence and development of renal cell carcinoma (RCC), there are dozens of genes involved in the reactions related to RCC metabolism, including the awareness of oxygen in the microenvironment, the uptake of iron and the uptake and utilization of nutrients, among which the most important one related to glucose metabolism is Tricarboxylic Regulation of fumarate hydrase (FH) and Succinate dehydrogenase (SDH) in TCA cycle [3].