Guo-Chang Fan et al. previously suggested that cGMP-PKG could phosphorylate HSPB6 in the circulatory system [11], leading us to speculate that a similar role may be played in prostate cancer, supported by the positive correlation between HSPP6 expression and genes of the cGMP-PKG signaling pathway. This evidence concerns the gene HSPB6 and Familial prostate cancer.