NOS3 and diabetic kidney disease: Potential candidate genes, such as leucine-rich alpha 2 glycoprotein (LRG1) and G protein-coupled receptor-56 (GPR56), enhancing angiogenesis induced by diabetes, have been identified [120], and GPR56 has been found to promote DKD through regulating eNOS mediated by coupling of Gα12/13-RhoA pathway activation and Gαi-mediated cAMP/PKA pathway inhibition [178].