A high clonal neoantigen burden in NSCLC is associated with an inflamed tumor microenvironment, enriched with activated effector T cells and the expression of proteins associated with T cell migration (CXCL10 and CXCL9), as well as negative regulators of T-cell activity including PD-L1 [11]. The gene discussed is CXCL10; the disease is non-small cell lung carcinoma.