SNCA and Parkinson disease: Lastly, the availability of a reporter to monitor mitochondrial-lysosomes tethering allowed us to identify the PD-related protein α-synuclein as a player in the regulation of this interface and to show that the re-organization of lysosome-mitochondria interface represents an early response to increased α-synuclein expression which in turn results in the calcium-dependent activation of TFEB.