PLOD1 and polycystic ovary syndrome: Ali et al. found that in the overweight and obese PCOS population (BMI ≥ 25 kg/m2), PIOMET treatment (30 mg/d for PIO and 1000 mg/d for MET) for 3 months effectively reduced LH levels in women with PCOS compared with MET monotherapy (1000 mg/d) [38].