INS and polycystic ovary syndrome: Ortega et al. showed that in an overweight/obese population with PCOS (BMI ≥ 25 kg/m2), fasting serum insulin concentration and AUCIns during a 2-h oral glucose tolerance test decreased after 6 months of MET (2550 mg/d) versus PIO (30 mg/d) treatment, with no significant difference between the two groups [56].