To answer this question, we analyzed the expression of p90RSK in a panel of HNSCC cell lines with high TMEM16A expression (Cal27, HN5, HN30, and HN31) compared to a panel of cells with low TMEM16A (OSC19, Te1, Te6, and SCC1) (Fig. 4A). The gene discussed is RPS6KA1; the disease is head and neck squamous cell carcinoma.