Among them, TAZ was up-regulated in tumor tissue compared with para-cancerous tissue, and the expression of the remaining eight genes (including SLC25A4, SLC25A5, PARK, PINK1, MFN2, HUWE1, VPS13D, and LRBA) was down-regulated in tumor tissue (Fig. 1D and E). Here, HUWE1 is linked to neoplasm.