Previous studies have demonstrated the association of Semaphorin-7A (Sema7A) with various diseases such as multiple sclerosis lesions [16], rheumatoid arthritis [17], acute aortic dissection [18], etc. It has been reported that CD163 may be a potential biomarker for infectious diseases [19], immune diseases [20], tumors [21] and Neurological Disorders [22]. This evidence concerns the gene SEMA7A and rheumatoid arthritis.