ITGAM and neoplasm: Interestingly, we observed increased infiltration of CD11b+CD11c+ immune cells (a phenotype of myeloid derived suppressor cells, MDSCs) [44] and monocytes in tumor region and invasive margin, and a decreased infiltration of B cells at the invasive margin of high-DPS group (Fig. 5H, I and Additional file 1: Fig S4).