Furthermore, we discovered that several of the human Gucy2d residues found to be modified in some LCA patients in the intracellular region are conserved in Drosophila Gucy2d (Fig S9C and Table S6) (Tucker et al, 2004; Li et al, 2011; Jacobson et al, 2013; de Castro-Miro et al, 2014; Zagel & Koch, 2014; Feng et al, 2020; Liu et al, 2020; Salehi Chaleshtori et al, 2020). The gene discussed is GUCY2D; the disease is Leber congenital amaurosis.