HRH3 and schizophrenia: Both the ACC and striatum were selected as the primary regions of interest (ROIs) based on preclinical findings of H3R’s role in glutamate release, along with being regions identified as having disrupted glutamate levels in schizophrenia (Molina-Hernández et al., 2001; Jin et al., 2009; Aquino-Miranda et al., 2016; Takei et al., 2017; Merritt et al., 2023).