Some examples that have been described in the literature include the occurrence of TSC2 variants and earlier onset of epilepsy (Alsowat et al., 2021), and epilepsy with an intellectual deficit (Dabora et al., 2001; Sancak et al., 2005; Au et al., 2007; Farach et al., 2019). The gene discussed is TSC2; the disease is epilepsy.