The main aim of this study was to investigate and assess the impact of administering various host-derived HCFs from different genotypes, obtained from both humans and animals, on cell proliferation, apoptosis sensitivity (measured by BAX/BCL-2 protein levels), and p53 gene expressions in human healthy liver hepatocytes and human hepatocellular carcinoma cells. This evidence concerns the gene TP53 and hepatocellular carcinoma.