ESR2 and neoplasm: For example, activation of ERβ with agonist ERB-041 in HCT-116, Caco2, and SW480 cell lines decreased cell survival, colonosphere formation, and migration while increasing the expression of ESR2, HPGD, CCND1, CTNNB1, CSLTR1, etc., suggesting the anti-tumor role of ERβ in CRC and the possible use of its agonist in the treatment of this disease [147].