Furthermore, multiple studies have demonstrated the anti-cancer efficacy of Nur77 agonist, 1,1-bis(3′-indolyl)-1-(phenyl)methane(DIM-C-Ph), 1,1-bis(3′-indolyl)-1-(p-anisyl)methane (DIM-C-pPhOCH3), in CRC cells. This evidence concerns the gene NR4A1 and cancer.