The significant role of several NRs such as Androgen Receptors (ARs), EAR2, Estrogen Receptors (ERs), Estrogen-related Receptors (ERRs), Farnesoid X Receptors (FXRs), Hepatocyte Nuclear Factor 4 alpha (HNF4α), Liver Receptor Homolog 1 (LRH-1), Liver X Receptors (LXRs), Nuclear Hormone Receptor 77 (Nur77), Progesterone Receptors (PRs), Peroxisome Proliferator-activated Receptors (PPARs), Pregnane X Receptors (PXR), Retinoid X Receptors (RXRs), Thyroid Hormone Receptors (THRs) and Vitamin D Receptors (VDRs) has been identified in CRC (Fig. 3). The gene discussed is ESR1; the disease is colorectal carcinoma.