Studies have also reported that berberine and its analog 3,9-dimethoxy-5,6-dihydroisoquinolino [3,2-a] isoquinolin-7-ium chloride (B-12) activate RXRα, which further leads to the reduction of cell growth by downregulating the Wnt/β-catenin pathway in CRC cells. This evidence concerns the gene RXRA and colorectal carcinoma.