In another study, it was observed that dehydroepiandrosterone (DHEA) and nerve growth factor (NGF) decreased, serum deprivation-induced apoptosis, but the treatment with testosterone led to increased apoptosis in colon cancer cell line (Caco2), suggesting the interplay between steroid hormones and neurotrophins signaling in hormone-dependent tumors [50]. This evidence concerns the gene NGF and malignant colon neoplasm.