The different NRs, such as AR, EAR 2, ER, ERR, FXR, HNF4α, LRH-1, LXR, Nur77, PPAR, PXR, PR, RXR, THR, and VDR, were found to modulate different signaling pathways such as NF-κB, Wnt/β-catenin, MAPK, etc. These NRs and their modulators (agonists/antagonists) were found to regulate various proteins and genes associated with major pathways involved in CRC progression, which subsequently led to the suppression of cell survival, proliferation, migration, invasion, and induction of apoptosis in CRC. The gene discussed is HNF4A; the disease is colorectal carcinoma.