WNK2 and neoplasm: Contrastingly, studies have also identified the tumor-promoting activity of HNF4α. For example, a study by Xu et al., showed that the increased expression of HNF4α induced by the overexpression of tumor-promoting lncRNA LINC00858, resulted in suppression of WNK lysine deficient protein kinase 2 (WNK2) and progression of carcinogenesis in colon cancer cells [175].