A bioactive component of green tea, epigallocatechin-3-gallate (EGCG), was also found to inhibit cell proliferation and induced G1/S phase cell cycle arrest by upregulating the expression of RXRα and suppressing β-catenin, cyclin D1, and DNA methyltransferase activity in CRC cell lines [127]. The gene discussed is CCND1; the disease is colorectal carcinoma.