Further, it was shown that various natural compounds and other agents like 5-Aza-CdR, quercetin, curcumin, ginseng, raloxifene, soy isoflavones, folic acid, genistein, resveratrol, and silymarin exhibit anti-cancer activity by modulating the expression of ER [146, 153, 162, 306, 307]. Here, ESR1 is linked to cancer.