PPARD and colorectal carcinoma: Moreover, Zou et al., has reported that GW501516, a PPARδ agonist, increased the expression of Glut1 and SLC1A5 in SW480 cells and enhanced the colitis-associated CRC by inducing pro-inflammatory genes, such as COX-2, IL-6, IL-8, and MCP-1 in AOM/DSS-exposed mice [220].