MAPK11 and amyotrophic lateral sclerosis: In ALS studies, miR-466q and miR-467f in MSC-Exos were shown to downregulate Mapk11, miR-466 m-5p, and miR-466i-3p to promote the nuclear translocation of Nrf2, and miRNAs regulate inflammatory responses and oxidative stress in astrocytes through anti-inflammatory and antioxidant activities (Provenzano et al. 2022).