Programmed death ligand-1 (PD-L1) plays a key role in negatively regulating tumor immune responses by suppressing T lymphocyte activity and is significantly correlated with tumor cell metastasis (Yao et al. 2019).sPD-L1 has been recognized as a diagnostic and prognostic biomarker in various cancer types. This evidence concerns the gene SPDL1 and neoplasm.