Calcium ion-binding proteins S100A8 (MRP8) and S100A9 (MRP14), along with S100A4, CA1 (carbonic anhydrase 1), and Annexin V (annexin 5) proteins were studied by Bansal et al., with reported significant differences in pre-and post-operative levels in BC patients (Bansal et al. 2016). This evidence concerns the gene CA1 and breast cancer.