A recent study by Amano et al., on the heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) expression, was shown to be significantly associated with lymph node metastasis and S100A8, S100A9, and uroplakin III expressions (Amano et al. 2021). The gene discussed is HNRNPA3; the disease is metastatic malignant neoplasm in the lymph nodes.