NFKB1 and neoplasm: Although MAX acts as a tumor suppressor in small cell lung cancer (Augert et al. 2020), it can also interact with NF-κB synergistically to promote Fas ligand expression in NSCLC and promote Fas related immune escape mechanism (Bennett et al. 1998; Kasibhatla et al. 2000; Wiener et al. 2004).