GCK and diabetes mellitus: Specifically, four loci, including the lncRNA gene locus LOC101929710 (lead SNP rs10476553), previously known to be associated with BMI, the ABCB11 (lead SNP rs853774) locus, related to severe cholestatic liver disease, the GCK (lead SNP rs730497) locus, associated with multiple types of diabetes, and the FOXA2 (lead SNP rs6048209) locus, linked to MODY, were specifically associated with baseline FPG and OGTT0H glucose levels but not OGTT1H and OGTT2H glucose levels (Fig. 2c–e, ESM Table 8).