By examining multiple pathways related to liver fibrosis, such as TGFβ/Smad pathway, Ras/ERK pathway, JAK/STAT pathway, and PI3K/AKT pathway, we found overexpression or knockdown of KIF18A only affected the expression of the effector proteins of PI3K/AKT pathway. The gene discussed is AKT1; the disease is Hepatic fibrosis.