Encouragingly, shRNAs against Dnmt3b, Pcgf6, and Mga were among those that are enriched after OGD treatment (Figure 1B), consistent with the notion that DNA methylation and polycomb repressive complexes play important roles in stroke injury and neuroprotection (Endres et al., 2000; Dock et al., 2015; Elder et al., 2013; Chen et al., 2019). Here, DNMT3B is linked to stroke disorder.