ELN and inflammatory response: We found that ECM receptor interactions are enhanced under high UCRScore transition, and metalloproteinases such as matrix metalloproteinases (MMPs) and other proteases activated by chronic inflammation can degrade collagen, elastin, and proteoglycans, leading to ECM structural destruction and sustained ECM remodeling and faulty tissue repair processes may lead to pathological fibrosis, affecting intestinal flexibility and function [44, 45].