Recently, the significance of PPM1G in liver diseases has been elucidated, as PPM1G complexes with WWP2 promote liver fibrosis by overactivating the Notch3/HES1 pathway and contributing to the growth of hepatocellular carcinoma by modulating SRSF3 phosphorylation.17, 18, 19. This evidence concerns the gene PPM1G and liver disorder.