In addition, Wang et al. confirmed that the enriched environment (EE) and melatonin (MEL) could improve the adverse effects of IUGR on the development of offspring rats by activating the IGF-1/IGFBP1 and IGF-1/mTOR/S6K1/4EBP1 signaling pathways and inhibiting autophagy (Wang et al., 2021). This evidence concerns the gene IGF1 and fetal growth restriction.